Interactions
Some medicines may enhance or counteract the effects of adrenaline, and patients may require management as a result of co-administration. However, as stated before there are no known contraindications to IM. adrenaline when used in life-threatening allergic reactions.
Drugs that may sensitise the heart to arrhythmias include digitalis, mercurial diuretics or quinidine.
Tricyclic antidepressants and monoamine oxidase inhibitors may also enhance the effects of adrenaline.
Pressor effects of adrenaline may be diminished by rapidly acting vasodilators or alpha-adrenergic blocking drugs.