Precautions
While the use of adrenaline requires caution in patients with coronary artery disease, it should be noted that untreated anaphylaxis is also associated with cardiac risks and adrenaline can actually improve blood flow in the coronary arteries.
Anyone taking beta blockers for cardiovascular disease may not respond well to adrenaline. Beta blockers interact with one of the receptor sites for adrenaline, antagonising its cardiostimulating and bronchodilating effects and potentially worsening anaphylaxis.
However, there is no absolute contraindication to the use of adrenaline in a life-threatening situation.